This tool can be used to identify COVID-19 positive patients who may have been infected by SARS-CoV-2 variants of concern (VOC), such as the Beta (B.1.351 – South Africa) lineage or Delta (B.1.167.2 – India) lineage.
*Research Use Only
SARS-CoV-2 Variants Description
The World Health Organization (WHO) has defined a SARS-CoV-2 isolate as a variant of interest (VOI) if it is phenotypically changed compared to a reference isolate of has a genome with mutations that lead to amino acid changes associated with established or suspected phenotypic implications; AND has been identified to cause community transmission/multiple COVID-19 cases/clusters, or has been detected in multiple countries.
A VOI is further classified as a variant of concern (VOC) if, through a comparative assessment, it has been demonstrated to be associated with:
- Increase in transmissibility of detrimental change in COVID-19 epidemiology;
- Increase in virulence or change in clinical disease presentation; or
- Decrease in effectiveness of public health and social measures or available diagnostics, vaccines, therapeutics.
WHO-designated variants of concern (VOCs) and selected variants of interest (VOIs), as of 4 August 2021.
|WHO Label||Pango Lineage||First identified||Mutation Panel Targets||Other spike protein substitutions|
|Beta||B.1.351||South Africa||E484K||D80A, D215G, 241/243del, K417N, N501Y, D614G, A701V|
|Gamma||P.1||Brazil||E484K||L18F, T20N, P26S, D138Y, R190S, K417T, N501Y, D614G, H655Y, T1027I, V1176F|
|Eta||B.1.525||Multiple countries||E484K||Q52R, A67V, 69/70del, 144del, D614G, Q677H, F888L|
|Epsilon||B.1.427/B.1.429||USA, California||L452R||S13I, W152C, D614G|
|Product||Pack Size||Contents||Catalogue No.|
|CoVClear Mutation Panel Reagent Pack||200 tests/kit||Reaction Master Mix, Enzyme Mix, Positive Control (WT+N), Negative Control||FGS0032R|
|CoVClear Mutation Panel E484K||200 tests/kit||Primer-Probe Mix (E484K+N), Positive Control (E484K+N)||FGS0035R|
|CoVClear Mutation Panel L452R||200 tests/kit||Primer-Probe Mix (L452R+N), Positive Control (L452+N)||FGS0036R|
Research Use Only (RUO).