RNA Interference (RNAi)

Research tools designed for RNA interference studies are used to suppress protein expression transiently or permanently, or to investigate the role of small RNA molecules in regulating gene expression.

The T7 RiboMAX™ Express RNAi System is an in vitro transcription system designed for efficient synthesis of milligram amounts of short interfering RNAs (siRNAs) or hairpin siRNAs (shRNAs) for mammalian RNAi studies.

The psiCHECK™ Vectors provide a quantitative and rapid approach for initial optimization of RNA interference. These vectors also are ideal for examining the effect of 3´ untranslated regions (3´ UTRs), such as miRNA target sequences, on gene expression.

The pmirGLO Vector is designed to quantitatively evaluate microRNA (miRNA) activity by the insertion of miRNA target sites downstream or 3´ of the firefly luciferase gene (luc2). Reduced firefly luciferase expression indicates the binding of endogenous or introduced miRNAs to the cloned miRNA target sequence.

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